Hein F.M. Lodewijkx, Bram Brouwer, Harm Kuipers and René van Hezewijk. Overestimated Effect of Epo Administration on Aerobic Exercise Capacity: A Meta-Analysis.
. 2013; 1(2):17-27. doi: 10.12691/AJSSM-1-2-2
aerobic performance, epo doping, meta-analysis, professional road racing
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[1] | Brouwer, B., Lodewijkx, H. F. M. and Kuipers, H., “Doping confessions of cyclists revisited.” [In Dutch: “Doping-bekentenissen van wielrenners langs de wetenschappelijke meetlat”]. Sportpsychologie Bulletin, 20: 24-37, 2009. |
|
[2] | Lodewijkx, H.F.M., Give some and take some: Cycling as double play. [In Dutch: Tussen geven en nemen: Wielrennen als dubbelspel]. 2010 Uitgevers, Rotterdam, 2011. |
|
[3] | Lodewijkx, H. F. M. and Brouwer, B. “Some empirical notes on the 'epo epidemic' in professional cycling.” Research Quarterly for Exercise and Sport, 82(4): 593-608, 2011. |
|
[4] | Lodewijkx, H. F. M. and Brouwer B., “Tour, Giro Vuelta: Rapid progress in cycling performance starts in the 1980s.” International Journal of Sports Science, 2(3): 24-31, 2012. |
|
[5] | Lodewijkx, H.F.M. and Verboon, P., “Lance Armstrong’s era of performance – Part 1: Are his time trial performances much different from other winners?” Journal of Athletic Enhancement, 2: 1, 2013. |
|
[6] | Lundby, C. and Olsen, N. V., “Effects of recombinant human erythropoietin in normal humans.” Journal of Physiology, 589(6):1265-1271, 2011. |
|
[7] | Ninot, G., Connes, P., and Caillaud, C., “Effects of recombinant human erythropoietin injections on physical self in endurance athletes.” Journal of Sports Sciences, 24: 383-391, 2006. (meta–analysis). |
|
[8] | Catlin, D. H., Hatton, C. K., and Lasne, F., “Abuse of recombinant erythropoietins by athletes.” In G. Molineux, M. A. Foote, and S. G. Elliott (Eds.), Erythropoietins and erythropoiesis. Birkhäuser Verlag, Basel, 2006, 205-228. |
|
[9] | Lasne, F., “Erythropoietin doping: Detection in urine.” In J. L.Fourcroy (Ed.), Pharmacology, doping and sport: Routledge, London, 2009, 107-124. |
|
[10] | Varlet-Marie, E., Gaudard, A., Audran, M., and Bressolle, F., “Pharmacokinetics / pharmacodynamics of recombinant human erythropoietins in doping control.” Sports Medicine, 33(4): 301-315, 2003. |
|
[11] | Bassett, D. R. and Howley, E. T., “Limiting factors for maximum oxygen uptake and determinants of endurance performance.” Medicine and Science in Sports and Exercise, 32: 70-84, 2000. |
|
[12] | Coyle, E. F., Coggan, A. R., Hopper, M. K., and Walters, T. J., “Determinants of endurance in well-trained cyclists.” Journal of Applied Physiology, 64: 2622-2630, 1988. |
|
[13] | Kuipers, H., “Putative effects of doping in cycling.” [In Dutch: “Vermeende effecten van doping in de wielersport”]. Nederlands Tijdschrift voor Geneeskunde, 150(48): 2643-2645, 2006. |
|
[14] | Lucia, A., Hoyos, J., Pérez, M., Santalla, A., and Chicharro, J. L., “Inverse relationship between VO2max and economy/efficiency in world-class cyclists.” Medicine and Science in Sports and Exercise, 34: 2079-2084, 2002. |
|
[15] | Lucia, A., Hoyos, J., Pérez, M., Santalla, A., Earnest, C. P., and Chicharro, J. L., “Which laboratory variable is related with time trial performance time in the Tour de France?” British Journal of Sports Medicine, 38: 636-640, 2004. |
|
[16] | Heuberger, J. A. A. C., Cohen-Tervaert, J. M., Schepers, F. M. L., Vliegenthart. A. D. B., Rotmans, J. I., Daniels, J. M. A., Burggraaf, J. and Cohen, A. F., “Erythropoietin doping in cycling: Lack of evidence for efficacy and a negative risk–benefit.” British Journal of Clinical Pharmacology, 2012. |
|
[17] | Hedges, L. V. and Olkin, I., Statistical methods for meta-analysis. Academic Press, New York, 1985. |
|
[18] | Rosenthal, R., Rosnow, R. L., and Rubin, D. B., Contrast and effect sizes in behavioral research: A correlational approach. Cambridge University Press, Cambridge, UK, 2000. |
|
[19] | Ashenden, M. J., Hahn, A. G., Martin, D. T., Logan, P., Parisotto, R., and Gore, C. J., “A comparison of the physiological response to simulated altitude exposure and r-HuEpo administration.” Journal of Sports Sciences, 19: 831-837, 2001. (meta–analysis). |
|
[20] | Audran, M., Gareau, R., Matecki, S., Duran, F., Chenard, C., Sicart, M.T. et al., “Effects of erythropoietin administration in training athletes and possible indirect detection in doping control.” Medicine and Science in Sports and Exercise, 31: 639-645, 1999. (meta–analysis). |
|
[21] | Balsom, P. D., Ekblom, B., and Sjodin, B., “Enhanced oxygen availability during high intensity intermittent exercise decreases anaerobic metabolite concentrations in blood.” Acta Physiologica Scandinavica, 150: 455-456, 1994. (meta–analysis). |
|
[22] | Birkeland, K. I., Stray-Gundersen, J., Hemmersbach, P., Hallen, J., Haug, E., and Bahr, R., “Effect of rhEPO administration on serum levels of sTfR and cycling performance.” Medicine and Science in Sports and Exercise, 32: 1238-1243, 2000. (meta–analysis). |
|
[23] | Connes, P., Caillaud, C., Mercier, J., Bouix, D., and Casties, J. F., “Injections of recombinant human erythropoietin increases lactate influx into erythrocytes.” Journal of Applied Physiology, 97(1): 326-332, 2004. (meta–analysis). |
|
[24] | Connes, P., Perry, S., Varray, A., Préfaut, C., and Caillaud, C., “Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (rHuEPO) treatment.” European Journal of Physiology, 447: 231-238, 2003. (meta–analysis). |
|
[25] | Ekblom, B. and Berglund, B., “Effect of erythropoietin administration on maximal aerobic power.” Scandinavian Journal of Medicine and Science in Sports, 1(2): 88-93, 1991. (meta–analysis). |
|
[26] | Lundby, C., Achman-Andersen, N. J., Thomsen, J. J., Norgaard, A. M., and Robach, P., “Testing for recombinant human erythropoietin in urine: Problems associated with current anti-doping testing.” Journal of Applied Physiology, 105: 417-419, 2008. (meta–analysis). |
|
[27] | Lundby, C. and Damsgaard, R., “Exercise performance in hypoxia after novel erythropoiesis stimulating protein treatment.” Scandinavian Journal of Medicine and Science in Sports, 16: 35-40, 2006. (meta–analysis). |
|
[28] | Lundby, C., Robach, P., Boushel, R., Thomsen, J. J., Rasmussen, P., Koskolou, M. et al., “Does recombinant human epo increase exercise capacity by means other than augmenting oxygen transport.” Journal of Applied Physiology, 105: 581-587, 2008. (meta–analysis). |
|
[29] | Parisotto, R., Gore, C. J., Emslie, K. R., Ashenden, M. J., Brugnara, C., Howe, C. et al., “A novel method utilizing altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes.” Haematologica, 85: 564-572, 2000. (meta–analysis). |
|
[30] | Rassmussen, P., Foged, E. M., Krogh-Madsen, R., Nielsen, J., Nielsen, T. R., Olsen, N. V. et al., “Effects of erythropoietin administration on cerebral metabolism and exercise capacity in men.” Journal of Applied Physiology, 109 (2): 476-483, 2010. (meta–analysis). |
|
[31] | Robach, P., Calbet, J. A. L., Thomsen, J. J., Boushel, R., Mollard, P., Rasmussen, P. et al., “The ergogenic effect of recombinant human erythropoietin on VO2max depends on the severity of arterial hypoxemia.” PLoS ONE, 3: 1-13, 2008. (meta–analysis). |
|
[32] | Russell, G., Gore, C. J., Ashenden, M. J., Parisotto, R., and Hahn, A. G., “Effects of prolonged low doses of recombinant human erythropoietin during submaximal and maximal exercise.” European Journal of Applied Physiology, 86: 442-449, 2002. (meta–analysis). |
|
[33] | Thomsen, J. J., Rentsch, R. L., Robach, P., Calbet, J. A. L., Boushel, R., Rasmussen, P. et al., “Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity.” European Journal of Applied Physiology, 101 (4): 481-486, 2007. (meta–analysis). |
|
[34] | Wilkerson, D. P., Rittweger, J., Berger, N. J. A., Naish, F., and Jones, A. M., “Influence of recombinant human erythropoietin treatment on pulmonary O2 uptake kinetics during exercise in humans.” Journal of Physiology, 568: 639-652, 2005. (meta–analysis). |
|
[35] | Rosenthal, R., “Parametric measures of effect size.” In H. Cooper and L. V. Hedges (Eds.), The handbook of research synthesis. Russell Sage Foundation, New York, 1994, 231-244. |
|
[36] | Egger, M., Smith, G. D., Schneider, M., and Minder, C., “Bias in meta-analysis detected by a simple, graphical test.” British Medical Journal, 315: 629-634, 1997. |
|
[37] | Cohen, J., Statistical power analysis for the behavioral sciences (2nd ed.). Lawrence Earlbaum Associates, Hillsdale, NJ, 1988. |
|
[38] | Nevill, A. M., Jobson, S. A., Palmer, G. S., Olds, T. S., “Scaling maximal oxygen uptake to predict cycling time-trial performance in the field: a non-linear approach”. European Journal of Applied Physiology, 94: 705-710, 2005. |
|
[39] | Jeukendrup, A. E., Craig, N. P., and Hawley, J. A., “The bioenergetics of World Class Cycling.” Journal of Science and Medicine in Sports, 3: 414-433, 2, 2000. |
|
[40] | Johnson, A. T., Biomechanics and exercise physiology: Quantitative modeling. CRCPress / Taylor and Francis Group, New York, 2007. |
|
[41] | Joyner, M. J., and Coyle, E. F., “Endurance exercise performance: The physiology of champions.” Journal of Physiology, 586: 35-44, 2008. |
|
[42] | Wilmore, J. H., Costill, D. L., and Kenney, W. L., Physiology of sport and exercise. Human Kinetics, Champaign, Il., 2008. |
|
[43] | Atkinson, G., Peacock, O., St Clair Gibson, A., and Tucker, R., “Distribution of power output during cycling: Impact and mechanisms.” Sports Medicine, 37: 647-667, 2007. |
|
[44] | Myburg, K. H., “What makes an endurance athlete world-class?: Not simply a physiological conundrum. Comparative Biochemistry and Physiology - part A. Molecular and Integrative Physiology, 136: 171-190, 2003. |
|
[45] | Hopkins, W. G., Hawley, J. A., and Burke, L. M., “Design and analysis of research on sport performance enhancement.” Medicine and Science in Sports and Exercise, 31: 472-485, 1999. |
|
[46] | Lucia, A., Earnest, C., and Arribas, C., “The Tour de France: a physiological review.” Scandinavian Journal of Medicine and Science in Sports, 13: 275-283, 2003 |
|