Effects of Acute Consumption of L-Carnitine Tartrate (LCLT) Following an Exhaustive Aerobic Exercise on Serum Lipoproteins Levels in Iranian Elite Wrestlers

Mostafa Dehghani^1, , Saeid Shakerian², Mohammad Kazem Gharib Nasseri³, Massood Nikbakht² and Sedigheh Heidari Nejad⁴

¹Department of Physiology, Physical Education and Sports Science Faculty, Shahid Chamran University, Ahvaz, Iran

²Department of Physiology, Physical Education Faculty, Shahid Chamran University, Ahvaz, Iran

³Physiology Research Center, Jondishapoor Medical Sciences University, Ahvaz, Iran

⁴Department of Sports Management, Physical Education Faculty, Shahid Chamran University, Ahvaz, Iran

Cite this paper

Mostafa Dehghani, Saeid Shakerian, Mohammad Kazem Gharib Nasseri, Massood Nikbakht and Sedigheh Heidari Nejad. Effects of Acute Consumption of L-Carnitine Tartrate (LCLT) Following an Exhaustive Aerobic Exercise on Serum Lipoproteins Levels in Iranian Elite Wrestlers. American Journal of Sports Science and Medicine. 2013; 1(4):59-62. doi: 10.12691/AJSSM-1-4-2

Abstract

Background and Objective: In this study, the effect of LCLT supplementation was investigated on serum levels of high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein following an exhaustive aerobic exercise in elite wrestlers. Materials and Methods: Twenty healthy elite male wrestlers with a mean age of 22.05 ± 2.6 years, mean weight of 77.10 ± 11.65 kg, mean height of 1.79 ± 0.06 cm, and mean body mass index of 23.79 ± 2.45 kg/m² were participated in this single-blind clinical trial. The subjects were selectively divided into two groups of supplement and placebo. Ninety minutes before performing Conconi protocol, the supplement group received 3 g of LCLT dissolved in 200 ml water plus 6 drops of lemon juice and the placebo group received 200 ml water plus 6 drops of lemon juice. Blood samples were collected 90 min before exercise, immediately after exercise, and 30 min after exercise from brachial vein and their serum lipoprotein concentrations were measured. The obtained data were analyzed by SPSS-16. Result: The findings showed that acute consumption of 3 g LCLT tartrate in the experimental group, compared with the placebo group, had a significant positive correlation with increment of high-density lipoprotein and decrement of low-density lipoprotein following an exhaustive aerobic activity, while no significant change was observed in very low-density lipoprotein. Conclusion: The findings of the present investigation indicate that supplementation instant LCLT effect significant change was observed in HDL, LDL and VLDL and concentrations.

Keywords

L-carnitine tartrate, high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein, exhaustive aerobic activity

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Shidfar, F. Mahan, L. Scout, S. Raymond, G. Background. Kraous food and the care process, 13th ed. Tehran: Khosravi; 2012; 254-5.
[2]	Karlic H, Lohninger A, Laschan C. Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes. J Mol Med; 2004; 81:435.
[3]	Rebouche CJ, Chenard CA. Metabolic fate of dietary carnitine in human adults: identification and quantification of urinary and fecal metabolites. J. Nutr 1991; 121:539.
[4]	Heinonen oj. Carnitine and physical exercise. Sport Med. 1996; 22 (2): 109-132.
[5]	Zeyner A, Harmeyer J. Metablic functions of L-carnitine and its effects as feed additive in horses. Areview Arch Tiererahr. 1999 52; (2): 115-138.
[6]	Robergs, R.A., Roberts S. Fundamental Principles of Exercise Physiology: For Fitness, Performance and Health. USA, McGraw Hill, 2000; pp 237-42.
[7]	Maughan R, Gleeson M, Greenhaff P.L. Biochemistry of exercise & training. USA, Oxford Medical Publications, 1997; pp131-3.
[8]	Ibrahim WH, Bailey N, Sunvold GD, Bruckner GG. Effects of carnitine and taurine on fatty acid metabolism and lipid accumulation in the liver of cats during weight gain and weight loss. Am J Vet Res 2003; 64(10):1265-77.
[9]	Stephens FB, Constantin-Teodosiu D, Laithwaite D, Simpson EJ, Greenhaff PL. Anacute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle. J Clin Endocrinol. Metab 2006; 91(12):5013-8.
[10]	Guarnieri G, Biolo G, Vinci P, Massolino B, Barazzoni R. Advances in carnitine in chronic uremia. J Ren Nutr. 2007; 17(1):23-9.
[11]	Karlic H, Lohninger A. Supplementation of L-carnitine in athletes: does it make sense? Nutrition 2004; 20(7):709-15.
[12]	Abramowicz WN, Galloway SD. Effects of acute versus chronic L-carnitine L-tartrate supplementation on metabolic responses to steady state exercise in males and females. Int J Sport Nutr Exercise Metab 2005; 15(4):386-400.
[13]	Eroǵlu H, Senel O, Güzel NA. Effects of acute L-carnitine intake on metabolic and blood lactate levels of elite badminton players. Neuro Endocrinol Lett 2008; 29(2): 261-6.
[14]	Stuessi C, Hofer P, Meier C, Boutellier U. L-carnitine and the recovery from exhaustive endurance exercise: a randomised, doubleblind, placebo-controlled trial. Eur J Appl Physiol 2005; 95(5-6): 431-5.
[15]	Shuaa Kazmi, M. Kimiagar, M. RastManners R. Sarreshteh,m. Taleban, F. A. Acute supplementation of L - carnitine level, blood lactic acid and anaerobic threshold distance on the treadmill to Rsydnbh. Journal of Kurdistan University of Medical Sciences. Autumn 2006; 10: 43-52
[16]	Ghandchi, z. Mahan, L. Scout, S. Raymond, G .Nutrition in Exercise and Sport. Kraous food and the care process, 13th ed. Tehran: Khosravi; 2012: 13: 194-254.
[17]	Bacurau R.F.P. Navarro, F. Bassit R.A. Does exercise training interfere with effects of L-carnitine supplementation? Nutrition 2003; 19 (4): 337-41.
[18]	Horleys. L-carnitine. A division of naturalac nutrition. Level 2. [cited on 2003]. Available from: htpp://horlrys. com
[19]	Stephens, F.B. Constantin-Teodosiu D, Greenhaff PL. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol 2007; 581 (Pt 2): 431-44.
[20]	Muller DM, Seim H, Kiess W, Loster H, Richter T. Effect of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adult. Metabolism. 2002; 51(11): 1389-91.
[21]	Colombani P, Wenk C, Kunz I. Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double-blind crossover field study. Eur J Appl Physiol Occup Physiol. 1996; 73: 434-439.